An efficient domino approach for the synthesis of multisubstituted pyrroles via gold/silver-catalyzed amination/cycloisomerization of (Z)-2-en-4-yn-1-ols

Abstract

An efficient and one-pot synthesis of multisubstituted pyrroles with high diversity and in a regioselective manner from the reactions of suitably substituted (Z)-enynols with amines or sulfon-amides under mild reaction conditions has been developed. This synthesis was realized via a cascade process in the presence of gold/silver (Au/Ag) or boron trifluoride·etherate/ gold/silver (BF3·Et2O/Au/Ag) catalysts, which could catalyze amination and cycloisomerization reactions in the same vessel. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.