Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven

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Abstract

Fucosylated glycans are involved in the molecular mechanisms that underpin neuronal development, learning and memory. The capacity to study the fucose-α(1–2)-glycan residues noninvasively in the human brain, is integral to understanding their function and deregulation. Five fucose crosspeaks were assigned to fucosylated glycans using invivo two-dimensional magnetic resonance Correlated SpectroscopY (2D L-COSY) of the brain. Recent improvements encompassed on the 3T Prisma (Siemens, Erlangen) with a 64-channel head and neck coil have allowed two new assignments. These are Fuc VI (F2:4.44, F1:1.37 ppm) and Fuc VII (F2: 4.29, F1:1.36 ppm). The Fuc VI crosspeak, close to the water resonance, is resolved due to decreased T1 noise. Fuc VII crosspeak, located between Fuc I and III, is available for inspection due to increased spectral resolution. Spectra recorded from 33 healthy men and women showed a maximum variation of up to 0.02 ppm in chemical shifts for all crosspeaks.

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Tosh, N., Quadrelli, S., Galloway, G., & Mountford, C. (2019). Two New Fucose-α (1–2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-54933-1

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