Recent studies have unequivocally established the link between FTO and obesity. FTO was biochemically shown to belong to the AlkB-like family DNA/RNA demethylase. However, FTO differs from other AlkB members in that it has unique substrate specificity and contains an extended C-terminus with unknown functions. Insight into the substrate selection mechanism and a functional clue to the C-terminus of FTO were gained from recent structural and biochemical studies. These data would be valuable to design FTO-specific inhibitors that can be potentially translated into therapeutic agents for treatment of obesity or obesity-related diseases. © 2010 Higher Education Press and Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Han, Z., Huang, N., Niu, T., & Chai, J. (2010). A loop matters for FTO substrate selection. Protein and Cell. Higher Education Press. https://doi.org/10.1007/s13238-010-0082-2
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