Complete genome comparison of duck hepatitis virus type 1 parental and attenuated strains

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Abstract

Two complete duck hepatitis virus type 1 (DHV-1) genomes, strain SY5 and its chicken embryos passage descendent vaccine strain ZJ-A, were compared and analyzed in order to identify possible sites of attenuation. Of the 205 nucleotide changes, 22 resulted in sense mutations, 174 produced nonsense mutations. Besides, there are 7 consistent nucleotides substitutions in 50UTR and 2 in 30UTR. Three of these 22 sense mutations resided in VP0, 6 exists in VP1, one exists in VP3, 3 exists in 2A2, 3 exists in 2C, one was detected in 3B and 5 was in 3D. These results suggested that VP0, VP1, 3D, and 50/30UTR may contribute to the attenuation of DHV-1 in chicken/ duck/embryos. The results provide a genetic basis for future manipulation of a DHV-1 infectious clone. © Springer Science+Business Media, LLC 2012.

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Wang, Y., Li, C., Chen, Z., Xu, B., Li, G., & Liu, G. (2012). Complete genome comparison of duck hepatitis virus type 1 parental and attenuated strains. Virus Genes, 45(2), 398–401. https://doi.org/10.1007/s11262-012-0767-0

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