Protein oxidation is an unavoidable consequence of aerobic metabolism. The oxidation of most proteins residues is non-repairable and may affect protein structure and function. In particular, protein cross-links arising from oxidative modifications are presumably toxic to cells because they may accumulate and induce protein aggregation. However, most of these irreversible protein cross-links remain partially characterized. Up to very recently, ditryptophan cross-links (Trp-Trp), in particular, have been largely disregarded in the literature. Here, we briefly review studies showing that Trp-Trp cross-links can be formed in proteins exposed to a variety of oxidants. The challenges to fully characterize Trp-Trp cross-links are discussed as well as their potential roles in protein dysfunction and aggregation.
CITATION STYLE
Paviani, V., Galdino, G. T., Dos Prazeres, J. N., Queiroz, R. F., & Augusto, O. (2018). Ditryptophan cross-Links as novel products of protein oxidation. Journal of the Brazilian Chemical Society, 29(5), 925–933. https://doi.org/10.21577/0103-5053.20170239
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