Increased adiposity and endometrial cancer risk

Abstract

Among all cancers, increasing body mass index is most strongly associated with endometrial cancer incidence and mortality. The molecular mechanisms underlying the role of obesity, and in particular the role of visceral fat, to the pathogenesis of endometrial cancer are becoming better understood. The current body of knowledge suggests several rational strategies, including behavioral, pharmaceutical, and surgical interventions, can be used to circumvent or derail the aberrant signaling pathways and hormonal abnormalities associated with obesity. Given the growing worldwide obesity epidemic, the development and availability of therapeutics, which can reduce the impact of obesity on endometrial cancer risk is imperative.