Hierarchical multiple-model Bayesian approach to transmural electrophysiological imaging

Abstract

Noninvasive electrophysiological (EP) imaging of the heart aims to mathematically reconstruct the spatiotemporal dynamics of cardiac current sources from body-surface electrocardiographic (ECG) data. This ill-posed problem is often regularized by a fixed constraining model. However, this approach enforces the source distribution to follow a pre-assumed spatial structure that does not always match the varying spatiotemporal distribution of current sources. We propose a hierarchical Bayesian approach to transmural EP imaging that employs a continuous combination of multiple models, each reflecting a specific spatial property for current sources. Multiple models are incorporated as an Lp-norm prior for current sources, where p is an unknown hyperparameter with a prior probabilistic distribution. The current source estimation is obtained as an optimally weighted combination of solutions across all models, the weight being determined from the posterior distribution of p inferred from ECG data. The accuracy of our approach is assessed in a set of synthetic and real-data experiments on human heart-torso models. While the use of fixed models (L1- and L2-norm) only properly recovers sources with specific structures, our method delivers consistent performance in reconstructing sources with various extents and structures. © 2014 Springer International Publishing.