Traumatic brain injury

Abstract

Traumatic brain injury (TBI) is one of the leading causes of disabilities and young adults’ death. Considering all the challenges faced in research involving this field, this book chapter analyses the 100 most cited TBI trials in order to provide methodological recommendations for designing future trials in TBI. A literature review of 100 most cited clinical trials in TBI between 2010 and 2015 was conducted using the web engine: Web of Science. Based on the CONSORT guidelines, a comprehensive discussion of the main findings is provided as to guide and help investigators in this field to design TBI clinical trials.