Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH -wildtype Glioblastoma: A Case Report and Literature Review

  • YAMAGUCHI J
  • MOTOMURA K
  • OHKA F
  • et al.
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Abstract

Glioblastoma multiforme (GBM) is an aggressive cancer type, with fewer than 3-5% of patients surviving for more than 3 years. We describe a 48-year-old right-handed man who presented with generalized seizure attacks. Magnetic resonance imaging (MRI) revealed a heterogeneous gadolinium-enhancing lesion in the left inferior parietal lobule. The patient underwent awake surgery, and tumor resection included abnormalities on T2-weighted MRI, with subcortical mapping used to identify the deep functional boundaries. After supratotal resection, the tumor was diagnosed as GBM without isocitrate dehydrogenase (IDH) 1 and 2 mutations. At a follow-up evaluation, 9 years and 2 months after the surgery, the patient appeared healthy, and no relapse or recurrence was observed. We present the case of a long-term survivor of IDH-wildtype GBM. This case suggests that supratotal resection with intra-operative awake brain mapping can improve survival without impairing the patient's neurological functions.

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YAMAGUCHI, J., MOTOMURA, K., OHKA, F., AOKI, K., TANAHASHI, K., HIRANO, M., … SAITO, R. (2021). Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH -wildtype Glioblastoma: A Case Report and Literature Review. NMC Case Report Journal, 8(1), 747–753. https://doi.org/10.2176/nmccrj.cr.2021-0120

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