Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

6Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

The hazardous substance from Procambarus clarkii could cause rhabdomyolysis. Mice were administered mashed muscles and gills, intestines, and glands (GIG) obtained from cooked crayfish by gavage. Three of seventy-two mice administered with GIG (with an incidence rate of 4.17 %) appeared to have rhabdomyolysis symptoms with the serum creatine kinase (CK) content increased by more than 5 times, as well as the pathological changes in livers, spleens, kidneys, and skeletal muscles. Furthermore, the cytotoxicity and hemolysis analysis of the palytoxin revealed that the methanol/water extracts from GIG of crayfish were not inhibited by ouabain effectively, which pointed out the hazardous substance causing rhabdomyolysis was not allergen or palytoxin. These research results could be valuable in further comprehensive experiments and lay a foundation for basic rhabdomyolysis research.

References Powered by Scopus

Serum alanine aminotransferase in skeletal muscle diseases

322Citations
N/AReaders
Get full text

A rapid and sensitive hemolysis neutralization assay for palytoxin

169Citations
N/AReaders
Get full text

New palytoxin-like molecules in Mediterranean Ostreopsis cf. ovata (dinoflagellates) and in Palythoa tuberculosa detected by liquid chromatography-electrospray ionization time-of-flight mass spectrometry

96Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The Emergence, Epidemiology, and Etiology of Haff Disease

16Citations
N/AReaders
Get full text

Outbreak of Haff disease caused by consumption of crayfish (Procambarus clarkii) in nanjing, China

14Citations
N/AReaders
Get full text

A comparison of eating safety and quality of live and dead freshwater crayfish (Procambarus clarkii) at different stages

12Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Chen, X. F., Lin, J. W., Pan, T. M., Cao, M. J., Shi, C. L., Cai, Q. F., & Liu, G. M. (2015). Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay. Fisheries Science, 81(3), 551–558. https://doi.org/10.1007/s12562-015-0856-9

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

43%

Researcher 3

43%

Professor / Associate Prof. 1

14%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 4

57%

Medicine and Dentistry 1

14%

Veterinary Science and Veterinary Medic... 1

14%

Environmental Science 1

14%

Save time finding and organizing research with Mendeley

Sign up for free