Plasma Vitamin B-12 Levels and Risk of Alzheimer’s Disease: A Case-Control Study

8Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Introduction: Vitamin B-12 deficiency is a frequent condition in the elderly population. High homocysteine levels, which can contribute to arterial damage and blood clots in blood vessels, usually indicate a deficiency in vitamin B-12. Different studies have shown an association of raised total homocysteine with incident Alzheimer’s disease. This study aimed to evaluate the association between vitamin B-12 levels and the risk of Alzheimer’s disease (AD). Methods: A case-control study with a sample size of 90 was conducted at Tertiary hospital, Kathmandu. The participants who visited the psychiatric outpatient department from 2019 onward at Tertiary hospital, Kathmandu, were recruited. The Mini-Mental State Examination (MMSE) was administered to the participants by a trained medical doctor. The medical doctor used the MMSE scores to classify the participants into two groups: the healthy control group and the AD group. Results: The AD group had higher percentages of hypertension (20.9%), diabetes (13.6%), smoking habit (27.3%), vitamin B-12 deficiency (22.7%), and alcohol consumption (13.8%) relative to the control group. Among these features, a significant association was found between alcohol and vitamin B-12 status and between systolic blood pressure and MMSE score. Conclusion: This study concluded that there is an association between low levels of vitamin B-12 and the risk of AD. Further studies are needed to determine the cause-effect.

Cite

CITATION STYLE

APA

Shrestha, L., Shrestha, B., Gautam, K., Khadka, S., & Mahara Rawal, N. (2022). Plasma Vitamin B-12 Levels and Risk of Alzheimer’s Disease: A Case-Control Study. Gerontology and Geriatric Medicine, 8. https://doi.org/10.1177/23337214211057715

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free