How to Identify Familial Premature Myocardial Infarction: Comparing Approaches to Identify Familial Hypercholesterolemia

Abstract

How best to identify families with premature myocardial infarction is unclear. Objective: We compared approaches to identify familial premature myocardial infarction in the general population using different familial hypercholesterolemia (FH) criteria and low-density lipoprotein (LDL) cholesterol cut-points. Design and Setting: Clinical and mutation criteria for FH and LDL cholesterol cut-points were applied for identification of familial premature myocardial infarction in 106,732 individuals from the Copenhagen General Population Study.