From a strain of Bacillus subtilis a new antifungal peptidolipid complex of the iturin group was isolated. This antibiotic complex contained six lipophilic β-amino acids with 3-amino-14-methylpentanoic acid as the predominant component. Iturin AL contains: 2 D-Asp, 1 L-Asp, 1 L-Glu, 1 L-Pro, 1 L-Ser, 1 D-Tyr and a mixture of 2.9 % iso-C14-β-amino acid, 30.7 % n-C14-β-amino acid, 15% iso-C15-β-amino acid, 9% anteiso-C15-β-amino acid, 35.3% iso-C15-β-amino acid and 4.5 % n-C16-β-amino acid. The structures of the β-amino acids were determined by combined GLC/MS. FAB mass spectroscopy revealed three M+H+ peaks (1,043,1,057, 1,071). Iturin AL could be resolved into six components by HPLC whose structures confirm the high amount of long chain β-amino acids. © 1983, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
CITATION STYLE
Winkelmann, G., Allgaier, H., Lupp, R., & Jung, G. (1983). Iturin al - a new long chain iturin a possessing an unusual high content of c16-β-amino acids. The Journal of Antibiotics, 36(11), 1451–1457. https://doi.org/10.7164/antibiotics.36.1451
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