Stable DNA branched junction molecules can be used as the building blocks for stick-figures in which the edges are double-helical DNA and the vertices correspond to the branch points of the junctions. Sticky- ended cohesion is used to direct the association of individual branched complexes. The sequences of these molecules are assigned by a sequence- symmetry minimization procedure. Successful ligation experiments include the oligomerization of individual three-arm and four-arm junctions, the assembly of a quadrilateral from four junctions with different sticky ends, and the recent construction of a molecule with the connectivity of a cube. Possible applications include the assembly of molecular electronic devices, the formation of macromolecular-scale zeolites to host biological complexes for diffraction analysis, and the development of new catalysts.
CITATION STYLE
Mitev, N., de Vaujany, F.-X., Laniray, P., Bohas, A., & Fabbri, J. (2019). Co-working Spaces, Collaborative Practices and Entrepreneurship (pp. 15–43). https://doi.org/10.1007/978-3-319-94487-6_2
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