Regulation of excitability by potassium channels

Abstract

Neurons express a large number of different voltage-gated potassium (Kv) channels with distinct biophysical and biochemical properties. Possibly, this diversity reflects the need to regulate and fine-tune neuronal excitability at various levels of complexity in space and time. In this context, Kv channels operating in the subthreshold range of action- potential firing are of particular interest. It is likely that these Kv channels play a prominent role in both propagating and integrating dendritic signaling, as well as axonal action-potential firing and propagation. © 2007 Springer-Verlag Berlin Heidelberg.