Development of a non-Blurring, dual-imaging (X-ray/fluorescence) tissue marker for localization of gastrointestinal tumors

Abstract

Non-blurring tissue marker detectable by both X-ray computed tomography (CT) and near-infrared fluorescence laparoscope (NIR-FL) was newly developed to localize gastrointestinal tumors both preoperatively and intraoperatively, and its usefulness was examined with an animal model. Hydrophobic NIR fluorophore and ethiodized oil were aggregated with polyglycerol polyricinoleate into polymersome. This aggregate of 300 ml was administered into the porcine stomach using gastroendoscope, and CT and NIR-FL were performed. Four injection points within a 1-cm radius were individually identified with both modalities immediately and 18 h after administration. This dual-imaging marker could contribute to both preoperative simulation and intraoperative navigation for laparoscopic gastrointestinal surgery.