Zebrafish behavioral models of ageing

Abstract

With lifespans rapidly increasing worldwide there has been a marked increase in age-related diseases-particularly those affecting cognition-that place a major socioeconomic burden on society. Despite this, much of what occurs during the aging process at a molecular level is poorly understood, facilitating the need for a greater understanding of the processes involved. In recent years, zebrafish have proved a useful model for the identification of genetic and cellular mechanisms affecting a variety of disease processes. Here we review the potential of zebrafish as a model for the study of cognitive ageing.