In Vitro study of Garcinia celebica L. Stem Barks against Hepatitis C virus and Hepatocellular Carcinoma

Abstract

In this study, we are focused on Garcinia celebica as anti-HCV activity against JFH1 strain genotype 2a. The extraction process employed the use of maceration method. Starting from n-hexane solvent and another residue. The extracts were then analysed with various doses of 20, 10, 5, 2.5, and 1.25 μg/mL for anti-HCV against JFH1 strain genotype 2a and anticancer against Huh7it-1 cell line. The extracts exhibited anti-HCV on 1.25 μg/mL and no sign of toxicity to Huh7it-1 cells. The extracts also expressed anticancer activity on 20, 10, 5, and 2.5 μg/mL with a high level of toxicity to Huh7it-1 cells. The results from this study suggest that Garcinia celebica may be necessary as an add-on therapy candidate for treating HCV infections and HCC.