Coaxial electrospray has been used effectively for several dual-emitter applications, but has not been utilized for the study of rapid in-source chemistry. In this paper, we report the fabrication of a coaxial, micro-volume dual-emitter through the modification of a manufacturer’s standard electrospray probe. This modification creates rapid mixing inside the Taylor cone and the ability to manipulate fast reactions using a variety of solvents and analytes. We demonstrate its potential as a low-cost, dual-emitter assembly for diverse applications through three examples: relative ionization in a biphasic electrospray, hydrogen-deuterium exchange, and protein supercharging. [Figure not available: see fulltext.].
CITATION STYLE
Sundberg, B. N., & Lagalante, A. F. (2018). Coaxial Electrospray Ionization for the Study of Rapid In-source Chemistry. Journal of the American Society for Mass Spectrometry, 29(10), 2023–2029. https://doi.org/10.1007/s13361-018-2004-0
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