Novel strategies for the discovery of plant-derived anticancer agents

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Abstract

Several plant secondary metabolites or their semisynthetic derivatives are used clinically as cancer chemotherapeutic agents. In this review, a multidisciplinary collaborative research program focused on the discovery of novel anticancer agents from tropical rainforest plants is described. This team approach has integrated aspects of botany, biology, and chemistry. Examples are presented of active compounds isolated and biologically evaluated in recent work in this project. © 1999 IUPAC.

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Kinghorn, A. D., Farnsworth, N. R., Soejarto, D. D., Cordell, G. A., Pezzuto, J. M., Udeani, G. O., … Shu, Y. Z. (1999). Novel strategies for the discovery of plant-derived anticancer agents. Pure and Applied Chemistry, 71(9), 1611–1618. https://doi.org/10.1351/pac199971091611

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