Testosterone and Physical Function

Abstract

Purpose of Review: The purpose of this review is to provide an overview of recent data on the relationship of testosterone with physical function. Recent Findings: The safety of testosterone treatment in older men who do not have hypogonadism has increasingly been questioned. In recent years, multiple studies have been performed to better understand the relationship between testosterone and physical function. Summary: Overall, the relationship between testosterone and physical function is unclear. Endogenous and exogenous testosterones are associated with favorable changes in body composition and, to a lesser extent, muscle strength. However, the relationship between testosterone and physical function is less clear in healthy older men. Exogenous testosterone is associated with favorable changes in body composition and strength, but further data are needed to understand if treatment is associated with functional improvements and ultimately decreased disability and morbidity.