Fluorescence in situ hybridization

Abstract

FISH is a powerful technique used to visualize specific cytogenetic abnormalities. Its most significant role in dermatology to date lies in its ability to aid in the diagnosis and management of ambiguous melanocytic lesions. Although recent studies have suggested that FISH can be used as a supplementary diagnostic tool in pigmented lesions, FISH must not be used as a stand-alone test, and it cannot replace traditional histopathologic analysis. One must correlate clinical, pathologic, and molecular information. "FISHing" in dermatology continues to evolve, and we look forward to future studies to further delineate its roles in various dermatologic diseases. © 2013 The Society for Investigative Dermatology.