Magnolia ethanol extract on growth of tumor in tumor mice S180

Abstract

This paper carries on anti-tumor activities research of the ethanol extract of Magnolia officinalis (MEE). Our results showed that MEE has obvious anti-tumor activities to transplanted tumor model of the mouse S180 sarcoma in vivo. The inhibitory rates of tumor in both MEE 1.0 g/kg and 2.0 g/kg were more than 50 %, however it has not showed a dose-dependent manner. Although it has less damage than cisplatin, MEE can inhibit the immune system by obviously suppressed the spleen index and thymus index. These results indicated the anti-tumor mechanism of MEE might be related to the depressing of immune organs. © 2012 Springer-Verlag GmbH.