A coagulation anomaly: Plasma being made non-clottable by adding thrombin, and clottable by thromboplastin-calcium of toluidine blue-thrombin

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Abstract

Plasma samples obtained from 3 cases of a severe hemorrhagic disorder with hypofibrinogenemia during pregnancy were not clotted by simple addition of thrombin but clotted with thromboplastin-calcium or toluidine blue-thrombin. Laboratory results revealed severe coagulation defects and elevated fibrinolytic activity. In these cases, fibrinogen concentration determined by a procedure of centrifugation after heating at 56°C was markedly higher than that obtained by adding thromboplastin-calcium or toluidine blue-thrombin. The facts suggest that a significant amount of digest products of fibrinogen by plasmin, which are still coagulable by heating and have an anticoagulant activity, must be present in the patients' plasma. © 1964, Tohoku University Medical Press. All rights reserved.

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Maki, M., Kikuchi, I., Watanabe, S., & Kikuchi, E. (1964). A coagulation anomaly: Plasma being made non-clottable by adding thrombin, and clottable by thromboplastin-calcium of toluidine blue-thrombin. The Tohoku Journal of Experimental Medicine, 84(3), 274–281. https://doi.org/10.1620/tjem.84.274

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