Bone metastasis from renal cell carcinoma

Abstract

The subjects of this study were 38 patients with bone metastasis out of 124 cases of primary renal cell carcinoma treated at the National Cancer Center Hospital. The risk factors affecting the development of bone metastasis were considered. It is quite natural for the occurrence rate to be high in patients at an advanced stage of disease. However, from histopathological investigations of primary lesions, a tendency for bone metastasis is often observed in alveolar-type, solid (sarcomatoid)-type and mixed-type tumors as classified on the basis of histologic structure, for granular cell subtype on the basis of classification by cell type, and for grades 3 and 4 on the basis of classification by nuclear grading. Although radiation therapy and tumor artery infusion therapy were performed for metastatic bone lesions, the results obtained this time appeared to suggest no notable improvements in objective findings.