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Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25

Journal of Antibiotics (2006) 59(2) 93-97
DOI: 10.1038/ja.2006.13
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Abstract

Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis of cholesteryl ester and triacylglycerol by mouse macrophages with IC50 values of 4.0 and 3.2 μM, respectively. © Japan Antibiotics Research Association.

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Uchida, R., Kim, Y. P., Namatame, I., Tomoda, H., & Ömura, S. (2006). Sespendole, a new inhibitor of lipid droplet synthesis in macrophages, produced by Pseudobotrytis terrestris FKA-25. Journal of Antibiotics, 59(2), 93–97. https://doi.org/10.1038/ja.2006.13

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