Metastases to the central nervous system

Abstract

Metastases to the central nervous system (CNS) are among the most feared complications of systemic malignant disease. Metastases to other organs are frequently compatible with a prolonged, functional life through various treatment modalities, whereas strategically located metastases to the CNS are often devastating both physically and emotionally. Paralysis, seizures, incontinence, dementia, and language and cognitive disabilities after the patient's lifestyle, and progressive deterioration follows. Despite the grim prognosis, the symptoms of some patients can be reversed by early diagnosis and treatment, so that the quality of life can be improved. Accurate detection and evaluation of extent are essential for planning the palliative treatment of CNS metastatic disease.