Background: During the pandemic [Influenza A(H1N1)pdm09] period in 2009-2010, an influenza A (Inf-A) virus with H1N2 subtype (designated as A/Eastern India/N-1289/2009) was detected from a 25 years old male from Mizoram (North-eastern India). Objective. To characterize full genome of the H1N2 influenza virus. Methods. For initial detection of Influenza viruses, amplification of matrix protein (M) gene of Inf-A and B viruses was carried out by real time RT-PCR. Influenza A positive viruses are then further subtyped with HA and NA gene specific primers. Sequencing and the phylogenetic analysis was performed for the H1N2 strain to understand its origin. Results: The outcome of this full genome study revealed a unique reassortment event where the N-1289 virus acquired it's HA gene from a 2009 pandemic H1N1 virus with swine origin and the other genes from H3N2-like viruses of human origin. Conclusions: This study provides information on possibility of occurrence of reassortment events during influenza season when infectivity is high and two different subtypes of Inf-A viruses co-circulate in same geographical location. © 2012 Mukherjee et al.; licensee BioMed Central Ltd.
CITATION STYLE
Mukherjee, T. R., Agrawal, A. S., Chakrabarti, S., & Chawla-Sarkar, M. (2012). Full genomic analysis of an influenza A (H1N2) virus identified during 2009 pandemic in Eastern India: Evidence of reassortment event between co-circulating A(H1N1)pdm09 and A/Brisbane/10/2007-like H3N2 strains. Virology Journal, 9. https://doi.org/10.1186/1743-422X-9-233
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