Abstract The H69CIS200 and H69OX400 cell lines are novel models of low-level platinum drug resistance developed from H69 human small-cell lung cancer cells with eight 4-day treatments of 200 ng/ml cisplatin and 400 ng/ml oxaliplatin, respectively. A recovery period was given between treatments to emulate the cycles of chemotherapy given in the clinic. The resistant cell lines were approximately twofold resistant to cisplatin and oxaliplatin, and ...
CITATION STYLE
Stordal, B., & Davey, R. (2009). Regrowth Resistance: Low-Level Platinum Resistance Mediated by Rapid Recovery from Platinum-Induced Cell-Cycle Arrest. In Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy (pp. 171–176). Humana Press. https://doi.org/10.1007/978-1-60327-459-3_21
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