Antifungal activity of garlic (Allium sativum) against Aspergillus niger and Aspergillus oryzaea

Abstract

Natural sources for treatments of different ailments has been considered as one of the best alternative in an antibiotic-resistant era. They are now considered as safe alternative to commercially prepared medication in the pharmaceutical industry. The antibiotic resistance has caused complications in the medical field, making minor infections difficult to treat. Scientists have now started focusing in the therapeutic potential of herbs and medicinal plants. Due to the development of resistance against fungi and limited availability of antifungal drugs, cases of fungal infections are increasing. Studies have reported the antifungal attribute of garlic and the susceptibility of some fungi to garlic’s active ingredient i.e Allicin. In our study, the antifungal effect of Allium sativum has been studied. The antifungal effect of fresh juice of Allium sativum was analyzed against Aspergillus niger and Aspergillus oryzae through disc diffusion method. The efficacy of the extract was compared, with the known antifungal drugs such as Amphotericin B (100μg) and Nystatin (100μg). The results indicated that garlic has more antifungal activity against various fungi as compare to known antifungal drugs used and the antimicrobial potential of garlic is worth investigating.