Identification and characterization of a novel epoxide hydrolase from mouse liver microsomes

Abstract

A novel form of epoxide hydrolase has been demonstrated and characterized in mouse liver microsomes. It differs from the previously demonstrated microsomal epoxide hydrolase in its substrate specificity and immunological characteristics. It has many properties in common with cytosolic epoxide hydrolase, including substrate specificity and kinetic parameters, and is postulated to be a membrane-bound form of cytosolic epoxide hydrolase.