Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

79Citations
Citations of this article
58Readers
Mendeley users who have this article in their library.

Abstract

Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional corepressors of the Snail family via an interaction with the SNAG domain. Ajuba LIM proteins interact with Snail in the nucleus on endogenous E-cadherin promoters and contribute to Snail-dependent repression of E-cadherin. Using Xenopus neural crest as a model of in vivo Snail- or Slug-induced EMT, we demonstrate that Ajuba LIM proteins contribute to neural crest development as Snail/Slug corepressors and are required for in vivo Snail/Slug function. Because Ajuba LIM proteins are also components of adherens junctions and contribute to their assembly or stability, their functional interaction with Snail proteins in the nucleus suggests that Ajuba LIM proteins are important regulators of epithelia dynamics communicating surface events with nuclear responses.

Cite

CITATION STYLE

APA

Langer, E. M., Feng, Y., Zhaoyuan, H., Rauscher, F. J., Kroll, K. L., & Longmore, G. D. (2008). Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. Developmental Cell, 14(3), 424–436. https://doi.org/10.1016/j.devcel.2008.01.005

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free