Albuminuria and glomerular damage in mice lacking the metabotropic glutamate receptor 1

24Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

The metabotropic glutamate (mGlu) receptor 1 (GRM1) has been shown to play an important role in neuronal cells by triggering, through calcium release from intracellular stores, various signaling pathways that finally modulate neuron excitability, synaptic plasticity, and mechanisms of feedback regulation of neurotransmitter release. Herein, we show that Grm1 is expressed in glomerular podocytes and that a glomerular phenotype is exhibited by Grm1crv4 mice carrying a spontaneous recessive inactivating mutation of the gene. Homozygous Grm1crv4/crv4 and, to a lesser extent, heterozygous mice show albuminuria, podocyte foot process effacement, and reduced levels of nephrin and other proteins known to contribute to the maintenance of podocyte cell structure. Overall, the present data extend the role of mGlu1 receptor to the glomerular filtration barrier. The regulatory action of mGlu1 receptor in dendritic spine morphology and in the control of glutamate release is well acknowledged in neuronal cells. Analogously, we speculate that mGlu1 receptor may regulate foot process morphology and intercellular signaling in the podocyte. Copyright © 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Puliti, A., Rossi, P. I. A., Caridi, G., Corbelli, A., Ikehata, M., Armelloni, S., … Rastaldi, M. P. (2011). Albuminuria and glomerular damage in mice lacking the metabotropic glutamate receptor 1. American Journal of Pathology, 178(3), 1257–1269. https://doi.org/10.1016/j.ajpath.2010.11.050

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free