Alternative methods in toxicology: Pre-validated and validated methods

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The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds. Advanced alternative methods and their combinations are also used for safety assessment of final products. Several alternative methods, which were scientifically validated and accepted by competent regulatory bodies, can be used for regulatory toxicology purposes, thus reducing or fully replacing living animals in toxicology experimentation. The acceptance of the alternative methods as valuable tools of modern toxicology has been recognized by regulators, including OECD, FDA and EPA.This paper provides a brief overview of the topic "alternative methods in toxicology" and focuses on pre-validated and validated alternative methods and their position in the modern toxicology. Copyright © 2011 Slovak Toxicology Society SETOX.




Kandárová, H., & Letaáiová, S. (2011). Alternative methods in toxicology: Pre-validated and validated methods. Interdisciplinary Toxicology, 4(3), 107–113.

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