Alternative methods in toxicology: Pre-validated and validated methods

38Citations
Citations of this article
90Readers
Mendeley users who have this article in their library.

Abstract

The development of alternative methods to animal experimentation has progressed rapidly over the last 20 years. Today, in vitro and in silico methods have an important role in the hazard identification and assessment of toxicology profile of compounds. Advanced alternative methods and their combinations are also used for safety assessment of final products. Several alternative methods, which were scientifically validated and accepted by competent regulatory bodies, can be used for regulatory toxicology purposes, thus reducing or fully replacing living animals in toxicology experimentation. The acceptance of the alternative methods as valuable tools of modern toxicology has been recognized by regulators, including OECD, FDA and EPA.This paper provides a brief overview of the topic "alternative methods in toxicology" and focuses on pre-validated and validated alternative methods and their position in the modern toxicology. Copyright © 2011 Slovak Toxicology Society SETOX.

Cite

CITATION STYLE

APA

Kandárová, H., & Letaáiová, S. (2011). Alternative methods in toxicology: Pre-validated and validated methods. Interdisciplinary Toxicology, 4(3), 107–113. https://doi.org/10.2478/v10102-011-0018-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free