Applications of sequence coevolution in membrane protein biochemistry

5Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

Recently, protein sequence coevolution analysis has matured into a predictive powerhouse for protein structure and function. Direct methods, which use global statistical models of sequence coevolution, have enabled the prediction of membrane and disordered protein structures, protein complex architectures, and the functional effects of mutations in proteins. The field of membrane protein biochemistry and structural biology has embraced these computational techniques, which provide functional and structural information in an otherwise experimentally-challenging field. Here we review recent applications of protein sequence coevolution analysis to membrane protein structure and function and highlight the promising directions and future obstacles in these fields. We provide insights and guidelines for membrane protein biochemists who wish to apply sequence coevolution analysis to a given experimental system.

Cite

CITATION STYLE

APA

Nicoludis, J. M., & Gaudet, R. (2018, April 1). Applications of sequence coevolution in membrane protein biochemistry. Biochimica et Biophysica Acta - Biomembranes. Elsevier B.V. https://doi.org/10.1016/j.bbamem.2017.10.004

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free