Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

Abstract

Objective: To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA 1c). Methods: Samples were collected from 128 type 2 diabetic patients (aged 19-90 years; male 72, female 56). The sera were analyzed for HbA 1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA 1c level, the patients were divided into three groups, group A (HbA 1c <7%, n=31), group B (7% <10%, n=48), and group C (HbA 1c >10%, n=49). The correlation of HbA 1c with lipid ratios & individual lipid indexes were analyzed. Results: With the increased level of HbA 1c, LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA 1c, without any significant differences between three groups. There was no significant correlation between HbA 1c and TG or HDL-C. With the increased level of HbA 1c, TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions: LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients. © 2012 Hainan Medical College.