Localized mRNA translation plays roles in dendrites and axons, but the regulatory mechanisms and downstream pathways are not well understood. An article in Cell by Yoon et al. (2012) shows that lamin B2, well known as a nuclear protein, undergoes regulated synthesis in axons, promoting mitochondrial function and axon survival. © 2012 Elsevier Inc.
Preitner, N., & Flanagan, J. G. (2012, February 23). Axonal mRNA Translation: An Unexpected Link to Axon Survival and the Mitochondrion. Neuron. https://doi.org/10.1016/j.neuron.2012.02.005