Immunotactoid glomerulopathy

Abstract

Immunotactoid glomerulopathy (ITG) describes a glomerular lesion with specific ultrastructural features of organized deposits, most often microtubular and/or in parallel arrays, usually with monotypic immunoglobulin staining. It is diagnosed in the absence of cryoglobulinemia and is often associated with underlying lymphoproliferative disease, which results in production of the pathogenic paraprotein with subsequent renal deposition. Treatment of such underlying diseases has shown beneficial results in some patients.