Investigation of Relationship Between Hypoxic Process and Cancer Stem Cells in Meningioma

Abstract

AIM: To investigate the relationship between cancer stem cells (CD133 and CD44) and HIF1α expression in meningioma. MATERIAL and METHODS: In an immunohistochemistry experiment, three expert pathologists examined 100 meningioma slides stained for HIF1α, CD133, and CD44 antibodies. Statistical analyses were performed using the SPSS 23 Statistics packet program. P values <0.05 were statistically significant. RESULTS: HIF1α staining was correlated with high grade (Grade 2) meningioma. Cytoplasmic staining was negatively correlated with meningioma grade. High grade meningioma was positive for nuclear HIF1α and showed increased cytoplasmic expression of CD44 and CD133. CONCLUSION: In accordance with previous studies, the level of hypoxia and HIF1α were correlated with meningioma grade. Furthermore, expression of HIF1α was correlated with expression of CD133 and CD44, which are cancer stem cell surface markers, as well as with meningioma grade. In light of these data, new treatment modalities related to CD44 and CD133 stem cell markers and to HIF1α may be developed.