Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1

  • Borchelt D
  • Wong P
  • Becher M
  • et al.
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Abstract

A review with 135 refs. Topics include: clin. and neuropathol. phenotypes of familial amyotrophic lateral sclerosis (FALS); etiol. factors/mechanisms in amyotrophic lateral sclerosis and FALS; functions of copper/zinc superoxide dismutase 1 (SOD1); properties of familial amyotrophic lateral sclerosis mutant SOD1; transgenic models of SOD1-linked FALS; factors governing the severity of disease. [on SciFinder(R)]

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Borchelt, D. R., Wong, P. C., Becher, M. W., Bruijn, L. I., Cleveland, D. W., Copeland, N. G., … Xu, Z.-S. (1997). Perspectives on the Mechanisms of Familial Amyotrophic Lateral Sclerosis Caused by Mutations in Superoxide Dismutase 1. In Metals and Oxidative Damage in Neurological Disorders (pp. 295–314). Springer US. https://doi.org/10.1007/978-1-4899-0197-2_15

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