Models for recognition of virally modified cells by immune thymus-derived lymphocytes

Abstract

Virus-immune effector T cells generated in vivo are specific for both the virus used and the H-2 type of the infected mouse. Genes mapping at H-2K or H-2D apparently serve as self markers. The mechanism underlying this function is, however, not understood. This paper summarizes models that seem, at present, to be feasible explanations for this phenomenon, and considers possible implications of the hypothesis that self-recognition may be mediated by way of the same V gene subset that codes for alloreactivity. © 1976 Springer-Verlag New York Inc.