Quantum Chemical Calculations for some Isatin Thiosemicarbazones

Abstract

Derivatives of isatin are reported to be present in mammalian tissues and body fluids (Casas et al., 1996; Agrawal & Sartorelli, 1978; Casas et al., 1994; Medvedev et al., 1998; Boon, 1997; Pandeya & Dimmock, 1993; Rodriguez-Arguelles et al., 1999; Casas et al., 2000) and possess antibacterial (Daisley & Shah, 1984), antifungal (Piscopo et al., 1987), and anti-HIV (Pandeya et al., 1998, 1999) activities. N-methylisatin--4’, 4’ – diethylthiosemicarbazone were also reported to have activity against the viruses such as cytomegalo and moloney leukemia viruses (Sherman et al., 1980; Ronen et al., 1987). With the help of combinatorial method, the cytotoxicity and antiviral activities of isaitin--thiosemicarbazones against the vaccine virus and cowpox virus-infected human cells were evaluated (Pirrung et al., 2005).