Application of biological surface adsorption index approach (BSAI) in characterization of interactions between gold nanoparticles and biomolecules

Abstract

The biological surface adsorption index approach (BSAI) presents a novel approach for characterization of nanoparticles (NPs) in biological sys-tems. It is used for identification and quantitation of intermolecular forces that govern the adsorption properties of biomolecules on NPs surface. BSAI presents very important step in characterization of NPs-biomolecules interactions. Knowledge about the mechanism of interactions could help in prediction of NPs eventual toxicity in biological systems. Gold NPs are very often used in medicine, cosmetics and pharmacy thus evaluation of potential toxicity of gold NPs is extremely important prior its application. In this paper BSAI approach was applied on gold NPs with three different size (5 nm, 15 nm and 30 nm). The results showed that interactions of gold NPs and biomolecules vary in dependence of the size of NPs. The results contribute in toxicity assessment of gold nanoparticles in combination with other analytical tools for toxicity assessment.