Genetics of marfan syndrome and loeys-dietz syndrome

Abstract

Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS) are two clinically related aortic aneurysm conditions. LDS shows significant clinical overlap with MFS as regards its vascular and skeletal features, including aortic root aneurysm, arachnodactyly, scoliosis, and pectus deformity. In this chapter, we will review the current knowledge of the genetic basis of both disorders.