Fatty acylation promotes fusion of transport vesicles with Golgi cisternae

114Citations
Citations of this article
32Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Two different methods, stimulation of transport by fatty acyl-coenzyme A (CoA) and inhibition of transport by a nonhydrolyzable analogue of palmitoyl-CoA, reveal that fatty acylation is required to promote fusion of transport vesicles with Golgi cisternae. Specifically, fatty acyl-CoA is needed after the attachment of coated vesicles and subsequent uncoating of the vesicles, and after the binding of the NEM-sensitive fusion protein (NSF) to the membranes, but before the actual fusion event. We therefore suggest that an acylated transport component participates, directly or indirectly, in membrane fusion.

Cite

CITATION STYLE

APA

Pfanner, N., Glick, B. S., Arden, S. R., & Rothman, J. E. (1990). Fatty acylation promotes fusion of transport vesicles with Golgi cisternae. Journal of Cell Biology, 110(4), 955–961. https://doi.org/10.1083/jcb.110.4.955

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free