Serum levels of human immunodeficiency virus type 1 (HIV-1) RNA after seroconversion: A predictor of long-term mortality in HIV infection

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Abstract

A cohort of 79 homosexual men with documented dates of human immunodeficiency vines type 1 (HIV-1) seroconversion and baseline CD4 cell counts of ≤500/μL were followed for up to 11.5 years. HIV-1 RNA was measured from stored sera obtained a median of 7 months after the estimated seroconversion date. AIDS progression and mortality among the men were studied, stratified by median baseline levels of HIV-1 RNA. AIDS progression rates at 11.5 years were 69% and 34%, respectively, among those with higher versus lower than median baseline virus loads (≤3040 copies/mL; P = .002), and mortality rates were 61% and 27%, respectively (P = .003). Survival curves continued to diverge throughout the 11.5 years, suggesting that the future clinical course of HIV-1 infection may already be determined at the earliest phases of disease. Initiation of definitive treatment very early in HIV-1 infection may be essential.

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Craib, K. J. P., Strathdee, S. A., Hogg, R. S., Leung, B., Montaner, J. S. G., O’Shaughnessy, M. V., & Schechter, M. T. (1997). Serum levels of human immunodeficiency virus type 1 (HIV-1) RNA after seroconversion: A predictor of long-term mortality in HIV infection. Journal of Infectious Diseases, 176(3), 798–800. https://doi.org/10.1086/517305

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