Memory CD8+ T cell protection

Abstract

Memory CD8+ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8+ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8+ T cell response will help optimize vaccine-induced CD8 + T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8+ T cells may affect the primary response. © Springer Science+Business Media New York 2013.