Gastric parietal cell antibodies, helicobacter pylori infection, and chronic atrophic gastritis: Evidence from a large population-based study in germany

Abstract

Background: Striking similarities between autoimmune gastritis and Helicobacter Pylori (H. pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting. Methods: Serum pepsinogen I and II, and antibodies against H. pylori in general, the cytotoxin-associated gene A protein (CagA) and parietal cells were measured by ELISA in 9,684 subjects aged 50 to 74 years. Antigastric parietal cell antibody (APCA) prevalence was examined in the overall population and according to sex, age, and H. pylori serostatus. The association between APCA prevalence andCAGwas assessed by logistic regression, overall and according to H. pylori status, controlling for potential confounding factors. Results: OverallAPCAprevalence was 19.5%.APCAprevalence was strongly associated with CAG, and the association was increasing with increasing severity of CAG. Furthermore, the association between APCA and CAGwas even stronger among H. pylori-negative subjects [odds ratio (OR)=11.3; 95% confidence interval (CI): 7.5-17.1)] than among H. pylori-positive subjects (OR = 2.6; 95% CI: 2.1-3.3). Conclusions:APCAmayplay a role on the development of gastric atrophy, irrespective of H. pylori infection. Impact: Assessment of APCA might be a useful complement to established markers (such as pepsinogens and H. pylori antibodies) in screening for CAG. Cancer Epidemiol Biomarkers Prev; 22(5); 821-6. © 2013 AACR.