The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology

14Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background. RhoJ, an endothelially expressed member of Cdc42 (cell division cycle 42) subfamily of Rho GTPase, plays an important role in endocytic pathway, adipocyte differentiation, endothelial motility, tube formation, and focal adhesion. RhoJ is a selective and effective therapeutic target in tumor tissues or retinopathy. Methods. A systematic review was related to "small Rho GTPase" or "RhoJ" with "endothelial motility, tube formation and focal adhesion" and "tumor therapy". This led to many cross-references involving RhoJ and these data have been incorporated into the following study. Results. We have grouped the role of RhoJ according to three main effects: RhoJ regulates endocytic pathway and adipocyte differentiation in early studies, and RhoJ shows an important role in endothelial cell biology; furthermore, RhoJ blockade serves as a target in tumor vasculature and enhances the effects of anticancer drug. Conclusions. More research is necessary to understand the role of RhoJ in many aspects, on the basis of current knowledge of the role of RhoJ blockade in tumor vessels, there are opportunities for the therapy of tumor, and RhoJ is expressed outside tumour vasculature and is involved in wound healing. Taking advantage of the opportunities could result in a development in tumor therapy.

References Powered by Scopus

Rho GTpases and the actin cytoskeleton

5346Citations
N/AReaders
Get full text

Molecular mechanisms and clinical applications of angiogenesis

4400Citations
N/AReaders
Get full text

Drug resistance and the solid tumor microenvironment

1816Citations
N/AReaders
Get full text

Cited by Powered by Scopus

RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

29Citations
N/AReaders
Get full text

Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients

27Citations
N/AReaders
Get full text

Actin cytoskeleton in angiogenesis

16Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Shi, T. T., Li, G., & Xiao, H. T. (2016). The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology. BioMed Research International. Hindawi Limited. https://doi.org/10.1155/2016/6386412

Readers over time

‘17‘18‘19‘20‘21‘22‘23‘24‘25036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 12

80%

Professor / Associate Prof. 1

7%

Lecturer / Post doc 1

7%

Researcher 1

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

38%

Biochemistry, Genetics and Molecular Bi... 6

38%

Engineering 2

13%

Agricultural and Biological Sciences 2

13%

Save time finding and organizing research with Mendeley

Sign up for free
0