The concentration of tumor necrosis factor in the blood serum and in the urine and selected early organ damages in patients with primary systemic arterial hypertension

Abstract

Arterial hypertension is considered to be an inflammatory condition with low intensity. Therefore, an elevated concentration of inflammatory cytokines can be expected in patients with systemic arterial hypertension, including tumor necrosis factor (TNF). The study included a group of 96persons aged 18to 65years: 76patients with primary arterial hypertension and 20healthy individuals (control group). Blood pressure was measured in all individuals using the office and ambulatory blood pressure monitoring (ABPM) measurement, blood was collected for laboratory tests [tumor necrosis factor (TNF), tumor necrosis factor receptor 1 (TNFR1)], and 24- hour urine collection was performed in which albuminuria and TNF concentration were assessed. Moreover, assessment of the intimamedia thickness (IMT) in ultrasonography and left ventricular mass index (LVMI) in echocardiography were carried out. Statistically elevated TNF concentration in the blood serum (P=.0001) and in the 24-hour urine collection (P=.0087) was determined in patients with hypertension in comparison with the control group. The TNF and TNFR1 concentration in the serum and TNF in the 24-hour urine in the group of patients with arterial hypertension and organ damages and without such complications did not differ statistically significantly. We observed a positive and statistically significant correlation between TNFR1 concentration in the serum and TNF urine excretion in patients with hypertension (r=0.369, P